A common disease of cats associated with abnormalities of aldosterone levels is primary hyperaldosteronism (Conn's syndrome), often diagnosed based on an elevated plasma aldosterone concentration and normal plasma renin activity. Conn's syndrome is often due to an adrenal adenoma or adrenal adenocarcinoma . Secondary hyperaldosteronism can result from reduced renal perfusion secondary to chronic renal disease or from rare instances of renin-secreting tumors.
A urine aldosterone:renin ratio can be a useful diagnostic tool, and levels of > 46.5 x 10-9 are indicative of normality.
Normal plasma levels of aldosterone are difficult to determine in cats and range from 0 - 1714 pmol/L, with plasma renin levels of 1.07 - 4.68 ng/mL/hr.
- ↑ Schulman RL (2010) Feline primary hyperaldosteronism. Vet Clin North Am Small Anim Pract 40(2):353-359
- ↑ Briscoe K et al (2009) Hyperaldosteronism and hyperprogesteronism in a cat. J Feline Med Surg 11(9):758-762
- ↑ Renschler JS & Dean GA (2009) What is your diagnosis? Abdominal mass aspirate in a cat with an increased Na:K ratio. Vet Clin Pathol 38(1):69-72
- ↑ Wong, L et al (2008) Reninoma: case report and literature review. J Hypertens 26:368
- ↑ Djajadiningrat-Laanen SC et al (2008) Urinary aldosterone to creatinine ratio in cats before and after suppression with salt or fludrocortisone acetate. J Vet Intern Med 22(6):1283-1288
- ↑ Refsal KR & Harvey, AM (2010) Primary hyperaldosteronism. In August, JR (Ed): Consultations in feline internal medicine. Vol 6. Elsevier Saunders, Philadelphia, pp:254