A common disease of cats associated with abnormalities of aldosterone levels is primary hyperaldosteronism (Conn's syndrome), often diagnosed based on an elevated plasma aldosterone concentration and normal plasma renin activity. Conn's syndrome is often due to an adrenal adenoma or adrenal adenocarcinoma . Secondary hyperaldosteronism can result from reduced renal perfusion secondary to chronic renal disease or from rare instances of renin-secreting tumors.
A urine aldosterone:renin ratio can be a useful diagnostic tool, and levels of > 46.5 x 10-9 are indicative of normality.
Normal plasma levels of aldosterone are difficult to determine in cats and range from 0 - 1714 pmol/L, with plasma renin levels of 1.07 - 4.68 ng/mL/hr.
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