Erythrocytosis (polycythemia) is defined by an increase in total red blood cell (RBC) number, packed cell volume (PCV), and hemoglobin (Hb) concentration above reference intervals.
The causes of erythrocytosis include:
- Absolute erythrocytosis - ↑RBCs, ↑PCV & ↑Hb due to an increase in RBC production (↑Erythropoietin)
- - Primary erythrocytosis - polycythemia vera - neoplastic myeloproliferative disorder (Erythropoietin independent)
- - Secondary erythrocytosis - a physiological response due to hypoxia - (↑Erythropoietin)
- - e.g. high altitude (> 1800 m), polycystic kidney disease, pyelonephritis, hydronephrosis, reverse patent ductus arteriosus, tetralogy of Fallot, severe chronic respiratory disease, hemoglobin function abnormalities, and severe obesity (Pickwickian syndrome)
- - e.g. neoplasia - renal cystadenoma, renal cystadenocarcinoma, renal lymphoma, renal adenocarcinoma, renal angiomyxoma, hepatoma, uterine leiomyoma and cerebellar hemangioblastoma.
- Relative erythrocytosis - ↑RBCs, ↑PCV & ↑Hb due to a decrease in total plasma fluid volume (hemoconcentration)
Clinical signs associated with erythrocytosis are directly related to an increase in blood viscosity and include diarrhea, vomiting, epistaxis, engorged retinal vessels, seizures, polyuria and polydipsia, dehydration and increased capillary refill time.
Blood tests usually reveal a PCV > 50%.
Primary absolute erythrocytosis is initially treated by phlebotomy to reduce the circulating RBC mass, removing 5 - 20 ml/kg of blood, while monitoring PCV. Administration of supplemental iron should be considered.
In polycythemia vera, phlebotomy is augmented with hydroxurea (myelosuppressive drug) at 50mg/kg orally once daily for seven days, followed by 15 mg/kg once daily until remission. The prognosis for animals with primary erythrocytosis is guarded.
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