From Dog

Allopurinol is a purine-analogue xanthine oxidase inhibitor used for treatment of canine Leishmania spp infections[1] and hyperuricosuria.

For urate uroliths, the recommended dose in dogs is 10 mg/kg every 8 hours.

For the treatment of canine leishmaniasis, allopurinol is dosed at 10 mg/kg every 12 hours for 4 - 6 months.

Side-effects such as hyperphosphatemia have been reported.


  1. Koutinas AF et al (2001) A randomised, blinded, placebo-controlled clinical trial with allopurinol in canine leishmaniosis. Vet Parasitol 98(4):247-261