From Dog

Amitriptyline and clomipramine are tricyclic antidepressants used for behavior modification and analgesia associated with neuropathic pain in dogs[1].

Good responses have been noted with use of this drug for obsessive compulsive disorder[2], separation anxiety[3] and aggression[4], although inferior to clomipramine.

Amitryptyline has also shown efficacy at pruritus reduction in atopy[5].

As it causes arachnoiditis when given epidurally, it should be given orally to dogs[6].

Recommended dose rate in dogs is 2 mg/kg given orally twice daily.


  1. Cashmore RG et al (2009) Clinical diagnosis and treatment of suspected neuropathic pain in three dogs. Aust Vet J 87(1):45-50
  2. Overall KL & Dunham AE (2002) Clinical features and outcome in dogs and cats with obsessive-compulsive disorder: 126 cases (1989-2000). J Am Vet Med Assoc 221(10):1445-1452
  3. Takeuchi Y et al (2000) Evaluation of treatments for separation anxiety in dogs. J Am Vet Med Assoc 217(3):342-345
  4. Virga V et al (2001) Efficacy of amitriptyline as a pharmacological adjunct to behavioral modification in the management of aggressive behaviors in dogs. J Am Anim Hosp Assoc 37(4):325-330
  5. Miller WH et al (1992) Nonsteroidal management of canine pruritus with amitriptyline. Cornell Vet 82(1):53-57
  6. Fukushima FB et al (2009) The neuraxial effects of intraspinal amitriptyline at low concentrations. Anesth Analg 109(3):965-971