From Dog

Angiolipoleiomyoma are rare benign mixed mesenchymal neoplasms of dogs[1].

These tumors, which can only be differentiated from lipoma and angiolipoma histologically, are composed of adipose, vascular, connective and smooth muscle tissue[2].

In dogs, few reports are evident, with one case of a uterine angiolipoleiomyoma diagnosed in an 11-year-old Pomeranian which presented with abdominal straining and a palpable abdominal mass[3].

These tumors should be distinguished histologically from lymphoma, adenocarcinoma and hemangiosarcomas.

Positive staining by Masson’s trichrome method and/or negative immunohistochemical staining for smooth muscle actin allow for easy differentiation of an angiolipoleiomyoma from and angiofibrolipoma.

The presence of smooth muscle cells not normally seen in lipoma and absence of nerves normally seen in adipose tissue are features that may allow differentiation[4].

Complete surgical excision is usually curative.


  1. Hendrick MJ et al (1998) Histological Classification of Mesenchymal Tumors of Skin and Soft Tissues of Domestic Animals, 2nd series, vol. II, pp. 19 and 43. Armed Forces Institute of Pathology, Washington, DC
  2. Kajo K et al (2010) Angiolipoleiomyoma of the uterus. Case report and literature review. Ceska Gynekol 75(1):54-56
  3. Boisclair J & Doré M (2001) Uterine angiolipoleiomyoma in a dog. Vet Pathol 38(6):726-728
  4. Gross TL et al (1992) Veterinary Dermatopathology: A Macroscopic and Microscopic Evaluation of Canine and Feline Disease, pp:430–433. Mosby Year Book, St. Louis, MO