Atovaquone (hydroxy-1,4-naphthoquinone) is a naphthoquinone analog.
This drug has poor water solubility and is usually incorporated into lipid-based formulations and requires to be given with a fatty meal for adequate absorption.
Recommended dose rate is 10 - 15 mg/kg with fatty meal given orally every 8 hours for 10 - 21 days.
- Sek L et al (2006) Examination of the impact of a range of Pluronic surfactants on the in-vitro solubilisation behaviour and oral bioavailability of lipidic formulations of atovaquone. J Pharm Pharmacol 58(6):809-820
- Lin EC et al (2012) The therapeutic efficacy of two antibabesial strategies against Babesia gibsoni. Vet Parasitol 186(3-4):159-164
- Di Cicco MF et al (2012) Re-emergence of Babesia conradae and effective treatment of infected dogs with atovaquone and azithromycin. Vet Parasitol 187(1-2):23-27