Borrelia spp are a Gram-negative, tick-borne zoonotic hemotropic parasitic proteobacteria which causes Lyme Disease of dogs in the United Kingdom, Asia and North and South America, predominantly in the Central and Eastern regions of the continent.
Species which are pathogenic to dogs include:
Lyme borreliosis is a multi-systemic disease that invades the skin, musculoskeletal and cardiovascular systems. This parasite, although associated with neurological symtpoms in some dogs, does not appear to have a direct role in etiopathogenesis of neurological signs.
Clinical signs associated with anaplasmosis include fever, arthropathy and nephritis in some cases. Central nervous system involvement, heart block, and uveitis are less frequently reported in dogs.
Hematological changes include thrombocytopenia, morulae in neutrophils, anemia, leukopenia, eosinopenia, lymphopenia, and monocytosis.
Diagnosis is by microscopic identification of parasites on blood smears, ELISA, Western blotting or PCR assays.
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- Smith FD et al (2012) Estimating Lyme disease risk using pet dogs as sentinels. Comp Immunol Microbiol Infect Dis 35(2):163-167
- Xia Z et al (2012) The occurrence of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis and Anaplasma phagocytophium in dogs in China. J Helminthol 86(2):185-189
- Bowman D et al (2009) Prevalence and geographic distribution of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis, and Anaplasma phagocytophilum in dogs in the United States: Results of a national clinic-based serological survey. Vet Parasit 160:138–148
- Ogden NH et al (2006) Climate change and the potential range expansion of the Lyme disease vector Ixodes scapularis in Canada. Intl J Parasitol 36:63–70
- Fritzen CM et al (2011) Infection prevalences of common tick-borne pathogens in adult lone star ticks (Amblyomma americanum) and American dog ticks (Dermacentor variabilis) in Kentucky. Am J Trop Med Hyg 85(4):718-723
- Woldehiwet Z (2010) The natural history of Anaplasma phagocytophilum. Vet Parasitol 167(2-4):108-122
- Barth C et al (2012) Prevalence of antibodies against Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum and their clinical relevance in dogs in Munich, Germany. Berl Munch Tierarztl Wochenschr 125(7-8):337-344
- Bowman DD (2011) Introduction to the alpha-proteobacteria: Wolbachia and Bartonella, Rickettsia, Brucella, Ehrlichia, and Anaplasma. Top Companion Anim Med 26(4):173-177
- Mircean V et al (2012) Seroprevalence and geographic distribution of Dirofilaria immitis and tick-borne infections (Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato, and Ehrlichia canis) in dogs from Romania. Vector Borne Zoonotic Dis 12(7):595-604
- Villeneuve A et al (2011) Seroprevalence of Borrelia burgdorferi, Anaplasma phagocytophilum, Ehrlichia canis, and Dirofilaria immitis among dogs in Canada. Can Vet J 52(5):527-530
- Aslan Başbulut E et al (2012) Seroprevalence of Borrelia burgdorferi and tick-borne encephalitis virus in a rural area of Samsun, Turkey. Mikrobiyol Bul 46(2):247-256
- Krimer PM et al (2011) Molecular and pathological investigations of the central nervous system in Borrelia burgdorferi-infected dogs. J Vet Diagn Invest 23(4):757-763
- Levy SA & Magnarelli LA (1992) Relationship between development of antibodies to Borrelia burgdorferi in dogs and the subsequent development of limb/joint borreliosis. J Am Vet Med Assoc 200:344–347
- Appel MJ et al (1993) Experimental Lyme disease in dogs produces arthritis and persistent infection. J Infect Dis 167:651– 664
- Hutton TA et al (2008) Search for Borrelia burgdorferi in kidneys of dogs with suspected “Lyme nephritis.” J Vet Intern Med 22:860–865
- Jacobson RH et al (1996) Lyme disease: laboratory diagnosis of infected and vaccinated symptomatic dogs. Semin Vet Med Surg (Small Anim) 11:172–182
- Wormser GP & O'Connell S (2011) Treatment of infection caused by Borrelia burgdorferi sensu lato. Expert Rev Anti Infect Ther 9(2):245-260
- McCall JW et al(2011) The ability of a topical novel combination of fipronil, amitraz and (S)-methoprene to protect dogs from Borrelia burgdorferi and Anaplasma phagocytophilum infections transmitted by Ixodes scapularis. Vet Parasitol 179(4):335-342