Carprofen is a nonsteoridal anti-inflammatory used for a wide range of inflammatory diseases in canine medicine.
There is good absorption from the gastrointestinal tract following oral administration. There is a high degree of protein binding and a small volume of distribution that is mostly to extracellular sites.
Carprofen is a weak acid and so it readily penetrates into inflamed tissue. Elimination is usually following metabolism by hepatic enzymes, and the less active metabolites are eliminated via a combination of faecal and urinary excretion. Urinary excretion of the unchanged drug is minimal, and relies on glomerular filtration and tubular excretion. There is also a degree of hepatic excretion and evidence of enterohepatic recycling.
Recommended dose rate in dogs is 2.2 mg/kg orally twice daily