From Dog

Chlorpheniramine is an antihistamine used for treatment of various allergic conditions in dogs[1].

This drug blocks histamine H1 receptor antagonist[2] and serotonin-norepinephrine reuptake inhibitor[3].

This drug has been used for atopy[4] (with limited success) and for various diseases associated with rhinitis.

Recommended dose rate in dogs is 1 - 2 mg given orally every 8 - 12 hours.


  1. Rudolph K et al (2003) A model of allergic nasal congestion in dogs sensitized to ragweed. Am J Rhinol 17(4):227-232
  2. Audibert G et al (1998) Effect of the H1 blocker d-chlorpheniramine on cerebral blood flow in the conscious dog during normocapnic hypoxia. Clin Physiol 18(1):27-33
  3. Carlsson, A & Linqvist M (1969) Central and peripheral monoaminergic membrane-pump blockade by some addictive analgesics and antihistamines. J Pharm Pharmacol 21(7):460–464
  4. Zur G et al (2002) Antihistamines in the management of canine atopic dermatitis: a retrospective study of 171 dogs (1992-1998). Vet Ther 3(1):88-96