Cisparide is a drug that has both antiemetic and prokinetic properties.
It enhances the release of acetylcholine in the smooth muscle of the gastrointestinal tract via its effects on serotonin receptors in the myenteric plexus.
Like metoclopramide, cisapride increases lower oesophageal sphincter pressure, gastric emptying and small intestinal motility.
While it has no direct effect on the central nervous system, it is effective at controlling vomiting due to gastroparesis (e.g. from post-operative ileus or infiltrative disease) or associated with recurrent constipation. Cisapride may also be used for gastroesophageal reflux that is unresponsive to H2-blockers such as ranitidine or omeprazole.
Because it is a prokinetic drug, cisapride is contraindicated for gastrointestinal blockages, and may cause diarrhoea and colic side effects when used. It has an interactive effect when used in conjunction with ketoconazole or other azoles, and should not be used when concurrent fungal infections are present.
The recommended dosage in dogs is 1.5 mg/kg orally twice daily.