From Dog

Cyclophosphamide is an immunosuppressive chemotherapy agent used for treatment of:

This drug is a nitrogen mustard alkylating agent derived from the oxazophorines group.

Mesna is sometimes used as an adjunct drug to reduce risks of side-effects such as hemorrhagic cystitis.

Levels of interferon are significantly increased in dogs receiving chemotherapy with cyclophosphamide used in conjunction with drugs such as toceranib[1].

Recommended dose rate in dogs is 200 - 250 mg/m2 given orally or intravenously.


  1. Mitchell L et al (2012) Clinical and immunomodulatory effects of toceranib combined with low-dose cyclophosphamide in dogs with cancer. J Vet Intern Med 26(2):355-362