Cyclophosphamide is an immunosuppressive chemotherapy agent used for treatment of:
- Cancer - primarily lymphoma
- Immune-mediated diseases in dogs.
- Chronic ulcerative keratitis secondary to canine herpesvirus
This drug is a nitrogen mustard alkylating agent derived from the oxazophorines group.
Recommended dose rate in dogs is 200 - 250 mg/m2 given orally or intravenously.
- Mitchell L et al (2012) Clinical and immunomodulatory effects of toceranib combined with low-dose cyclophosphamide in dogs with cancer. J Vet Intern Med 26(2):355-362