Cyniclomyces spp

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Cyniclomyces guttulatus visualized under light microscopy from dog feces

Cyniclomyces spp are an opportunistic ascomycetous yeast commonly found in the gastrointestinal tract of dogs worldwide[1].

These yeasts are normally found in the gastrointestinal lining of dogs and cats, but a higher percentage are found in domestic and feral rabbits, guinea pigs, and chinchillas[2].

Species which are pathogenic to dogs include:

  • Cyniclomyces guttulatus [3]

Diseases associated with this yeast are rare, but an association with inflammatory bowel disease[4] and choloecystitis have been reported.

Most dogs present with vomiting and diarrhea. On cases of cholecystitis, signs referable to acute hepatitis and cholecystitis are observed[5].

Diagnosis is based on isolation and identification of yeast in feces or viscera under light microscopy.

Recommended treatment is nystatin, given orally at 500,000 IU/kg daily for 4 - 7 days[6].


  1. Flausino G et al (2012) Isolation and Characterization of Cyniclomyces guttulatus (Robin) Van Der Walt and Scott, 1971 in Dogs in Brazil. Curr Microbiol 65(5):542-546
  2. Zierdt CH et al (1988) Cyniclomyces guttulatus (Saccharomycopsis guttulata) - culture, ultrastructure and physiology. Antonie Van Leeuwenhoek 54(4):357-366
  3. Gjerde, B et al (2009) A Cyniclomyces gutitulatus-like yeast associated with recurrent gastroenteritis in a dog. Norsk Veterinærtidsskrift 121(6):507-510
  4. Dijkstra M et al (2010) Protein-losing enteropathy in Rottweilers. Tijdschr Diergeneeskd 135(10):406-412
  5. Neel JA et al (2006) Gallbladder aspirate from a dog. Vet Clin Pathol 35(4):467-470
  6. Peters S & Houwers DJ (2009) A cat with diarrhoea associated with the massive presence of Cyniclomyces guttulatus in the faeces. Tijdschr Diergeneeskd 134(5):198-199