From Dog

Difloxacin hydrochloride is a broad-spectrum fluoroquinolone antimicrobial drug active against Gram-positive and Gram-negative bacteria, but with less potency than enrofloxacin[1] or pradofloxacin[2].

Difloxacin inhibits bacterial DNA gyrase and the topoisomerase II enzyme, which inhibits DNA replication and transcription.

It is active against Staphylococcus aureus, E. coli, Enterobacter spp and Pseudomonas aeruginosa, but resistance has been reported[3].

Recommended dose rate in dogs is 5 - 10 mg/kg given orally every 24 hours.


  1. Awji EG et al (2012) Comparative mutant prevention concentration and mechanism of resistance to veterinary fluoroquinolones in Staphylococcus pseudintermedius. Vet Dermatol 23(4):376-380
  2. Schink AK et al (2013) Susceptibility of canine and feline bacterial pathogens to pradofloxacin and comparison with other fluoroquinolones approved for companion animals. Vet Microbiol 162(1):119-126
  3. Gebru E et al (2012) Mutant prevention concentration and phenotypic and molecular basis of fluoroquinolone resistance in clinical isolates and in vitro-selected mutants of Escherichia coli from dogs. Vet Microbiol 154(3-4):384-394