Digoxin is a purified cardiac glycoside extracted from the foxglove plant, Digitalis lanata.
It is the only positive inotrope, negative chronotrope used in canine medicine for treatment of dilated cardiomyopathy and atrial fibrillation.
Digoxin works by inhibition of the Na+/K+ ATPase and direct and indirect sympatholytic/parasympathomimetic actions.
Recommended dose rate is 0.005 - 0.010 mg/kg orally twice daily.
- Muir WW et al (1999) Textbook of Canine and Feline Cardiology-Principles and Clinical Practice. 2nd edition, Philadelphia, W.B. Saunders. Chapter 17. pp:307-330