From Dog

Diltiazem is a calcium-channel blocker used for the treatment of atrial fibrillation, supraventricular tachycardias, hypertrophic cardiomyopathy, and hypertension.

This drug is also a bronchodilator, causing relaxation of proximal and distal airways, similar in effect to terbutaline and aminophylline, but whose mechanism of action differs[1].

Side-effects with this drug have been reported in breeds such as the Collie with multi-drug sensitivity.

The recommended dose rate for dogs is 0.5 - 1.5 mg/kg orally three times daily.


  1. Akhtar S et al (1999) Differential bronchodilatory effects of terbutaline, diltiazem, and aminophylline in canine intraparenchymal airways. Crit Care Med 27(8):1551-1556