From Dog

Dimenhydrinate is an antiemetic agent which acts centrally on H1 receptors[1] and is used for control of vomiting[2].

Although primarily used for motion sickness, it can also be used for control of vomiting associated with acute gastroenteritis.

Recommended dose rate in dogs is 12.5 mg/kg given orally every 8 - 12 hours.


  1. Hahn N et al (1975) The effect of a dimenhydrinate combination of the cardiovascular system and cerebral blood circulation in the anaesthetized dog. Arzneimittelforschung 25(2):208-213
  2. Wang C et al (2007) Development and validation of a liquid chromatography/tandem mass spectrometry assay for the simultaneous determination of D-amphetamine and diphenhydramine in beagle dog plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci 854(1-2):48-56