Edrophonium (Tensilon) is a short-acting acetylcholinesterase inhibitor which acts on neuromuscular junctions in muscle.
In dogs, this drug is primarily used to assist a clinical diagnosis of myasthenia gravis and dogs which respond to this drug, showing improved muscle performance, suggest an underlying MG predisposition.
Recommended dose rate in dogs is 0.5 - 2.5 mg/dog given intravenously.
- Foy DS et al (2011) Cholinergic crisis after neostigmine administration in a dog with acquired focal myasthenia gravis. J Vet Emerg Crit Care (San Antonio) 21(5):547-551
- Clutton RE (1994) Edrophonium for the antagonism of neuromuscular blockade in dogs. Vet Rec 134(26):674-678