From Dog

Enilconazole is a topical mycotic agent used as a topical application for fungal infections[1].

In dogs, it has primarily been used to treat Microsporum spp[2] and Aspergillus spp infections[3], either as a single topical agent or in combination with oral itraconazole[4] or griseofulvin.

Long-term outcomes with this drug is good, with most dogs being asymptomatic throughout the treatment period, with only some showing signs of rhinitis/sinusitis[5].

Enilconazole is usually applied as a 5% solution (1:1 in water) topically every 12 hours for 7 - 10 days, or as an instillation into the nasal sinuses as a 10 - 20 mg/kg solution (10% solution: 50:50 in water), irrigated twice daily for 10 - 14 days[6].


  1. Moriello KA (2004) Treatment of dermatophytosis in dogs and cats: review of published studies. Vet Dermatol 15(2):99-107
  2. Andrino M et al (2003) Canine onychomycosis produced by Microsporum gypseum. A case report. Rev Iberoam Micol 20(4):169-171
  3. Sharman M et al (2012) Clotrimazole and enilconazole distribution within the frontal sinuses and nasal cavity of nine dogs with sinonasal aspergillosis. J Small Anim Pract 53(3):161-167
  4. Claeys S et al (2006) Surgical treatment of canine nasal aspergillosis by rhinotomy combined with enilconazole infusion and oral itraconazole. J Small Anim Pract 47(6):320-324
  5. Schuller S & Clercx C (2007) Long-term outcomes in dogs with sinonasal aspergillosis treated with intranasal infusions of enilconazole. J Am Anim Hosp Assoc 43(1):33-38
  6. Billen F et al (2010) Efficacy of intrasinusal administration of bifonazole cream alone or in combination with enilconazole irrigation in canine sino-nasal aspergillosis: 17 cases. Can Vet J 51(2):164-168