Epitheliotropic T-cell lymphoma
The disease is characterized by an indolent infiltration of neoplastic lymphocytes in the skin with a specific tropism for the epidermis and adnexal epithelium. Progression of disease may take years in some dogs.
Dogs often present with ulcerative stomatitis with no significant or only minor abnormalities on haematology and serum biochemistry panels. The skin shows varying degrees of erythematous, scaly and alopecic macules, patches or plaques. Lymphadenopathy is a rare accompanying presentation. no buccal lesions appear as multifocal flaccid bulla lesions filled with proteinaceous fluid that spontaneously rupture.
Diagnosis is usually based on presenting clinical signs and histopathological analysis of biopsied skin. Early-stage epitheliotropic T-cell lymphoma can clinically and histologically mimic a large range of inflammatory dermatoses and exclusion of other diseases is important before establishing a definitive diagnosis.
The histological appearance often takes on the forms of mycosis fungoides, pagetoid reticulosis or Sézary syndrome.
Immunohistochemistry is often employed to further characterize the tumor and distinguish it from erythema multiforme, and PCR assays are currently available for detection of T-cell receptor gamma (TCRgamma) rearrangements.
Buccal forms of this disease can progress rapidly and aggressively, leading to violent, uncontrollable pruritus, which may be disturbing for the owner.
The prognosis is considered to be poor, with survival times from few months to 2 years.
Dogs are usually euthanized in cases that progress to high-grade lymphoma or have poor quality of life.
- ↑ Bhang DH et al (2006) Epitheliotropic cutaneous lymphoma (mycosis fungoides) in a dog. J Vet Sci 7(1):97-99
- ↑ Wikipedia
- ↑ Moore PF et al (2009) Canine epitheliotropic cutaneous T-cell lymphoma: an investigation of T-cell receptor immunophenotype, lesion topography and molecular clonality. Vet Dermatol 20(5-6):569-576
- ↑ Chimura N et al (2011) Gene transcription analysis in lesional skin of canine epitheliotropic cutaneous lymphoma using quantitative real-time RT-PCR. Vet Immunol Immunopathol 144(3-4):329-336
- ↑ Affolter VK et al (2009) Indolent cutaneous T-cell lymphoma presenting as cutaneous lymphocytosis in dogs. Vet Dermatol 20(5-6):577-585
- ↑ Nemec A et al (2012) Erythema multiforme and epitheliotropic T-cell lymphoma in the oral cavity of dogs: 1989 to 2009. J Small Anim Pract 53(8):445-452
- ↑ Bizikova P et al (2009) Canine cutaneous epitheliotropic T-cell lymphoma with vesiculobullous lesions resembling human bullous mycosis fungoides. Vet Dermatol 20(4):281-288
- ↑ Fontaine J et al (2010) Canine cutaneous epitheliotropic T-cell lymphoma: a review of 30 cases. Vet Dermatol 21(3):267-275
- ↑ Shiomitsu K et al (2012) Cutaneous epitheliotropic lymphoma with dual CD3 and c-kit expression in a dog. Vet Clin Pathol Oct 19
- ↑ Chaubert P et al (2010) Improved polymerase chain reaction-based method to detect early-stage epitheliotropic T-cell lymphoma (mycosis fungoides) in formalin-fixed, paraffin-embedded skin biopsy specimens of the dog. J Vet Diagn Invest 22(1):20-29
- ↑ Williams LE et al (2006) CCNU in the treatment of canine epitheliotropic lymphoma. J Vet Intern Med 20(1):136-143
- ↑ Risbon RE et al (2006) Response of canine cutaneous epitheliotropic lymphoma to lomustine (CCNU): a retrospective study of 46 cases (1999-2004). J Vet Intern Med 20(6):1389-1397
- ↑ Magnol JP et al (1996) Clinical, morphologic and immunophenotypic data based on 10 cases of canine muco-cutaneous epidermotropic T-lymphoma (analogous to Mycosis Funcgoïde). Important of an animal model of spontaneous pathology. Bull Acad Natl Med 180(2):449-462