Familial juvenile glomerulonephropathy
This disease is reported in several breeds of dogs and the mode of inheritance and spectrum of pathological lesions vary amongst breeds.
Hematological examination reveals varying degrees of azotemia and hyperkalemia.
Urinalysis invariably reveals proteinuria and sometimes haematuria.
Definitive diagnosis requires histopathological analysis of renal biopsies. Usually there is varying degrees of cystic glomerular atrophy, glomerular hypercellularity, and capillary wall thickening without immune complex deposition (when tested with immunohistochemistry or immunofluorescence), as well as ultrastructural abnormalities in the glomerular basement membrane, characteristic of 'end-stage' kidneys.
Survival rates are poor, with most patients succumbing to renal failure within 6 - 12 months of diagnosis, without renal transplantation.
- Lavoué R et al (2012) Progressive juvenile glomerulonephropathy in 16 related French Mastiff (Bordeaux) dogs. J Vet Intern Med 24(2):314-322
- Hood JC et al (1990) Hereditary nephritis in the bull terrier: evidence for inheritance by an autosomal dominant gene. Vet Rec 126(18):456-459