Familial stomatocytosis-hypertrophic gastritis
Although canine stomatocytosis has been described in purebred Alaskan Malamutes, Drentse Patrijshonds and Miniature Schnauzers, stomatocytosis-hypertrophic gastritis has mainly been reported in the Drentse Patrijshond and West Highland White Terrier and Old English Sheepdog.
Affected dogs usually present with a history of chronic vomiting, diarrhoea, icterus, ataxia, paresis, mild regenerative anemia and hypoalbuminaemia. In addition to hypertrophic gastritis, affected dogs exhibit abnormal blood phospholipid composition.
Biochemical analysis of stomach lining in this condition has shown that the general phospholipid composition and the molecular composition of phosphatidylcholine from mucosal tissue in the corpus of the stomach where hypertrophic gastritis was evident is not significantly different from normal gastric, suggesting only a weak correlation between gastric mucosal phospholipid composition and hypertrophic gastritis.
There is no known treatment for this hereditary condition and therapy is usually symptomatic.
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