This drug is metabolized to its inactive metabolite, 2',2'-difluorodeoxyuridine following intravenous injection, and is metabolized by the liver in linear kinetic rates and finally excreted in the urine. It has a half-life of about 12 hours in vitro.
This drug has shown efficacy either alone or in combination with carboplatin against canine transitional cell carcinoma, nasal carcinoma, osteosarcoma, hepatic carcinoma and mammary tumors.
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