From Dog

Glipizide is an oral sulfonylurea drug rarely used for treatment of canine diabetes mellitus.

Sulfonylureas are thought to act by stimulating the release of insulin from functional β cells. These drugs also have extrapancreatic effects on adipocytes, stimulating glucose transport and stimulating glycogenesis[1].

Unlike metformin, this drug has some effectiveness at controlling hyperglycemia, but its efficacy it not as modest at that observed in human patients[2].

Recommended dose rate in dogs is 2.5 - 5.0 mg twice daily, often given in conjunction with insulin.


  1. Müller G et al (1995) Extrapancreatic effects of sulfonylureas - a comparison between glimepiride and conventional sulfonylureas. Diabetes Res Clin Pract 28:S115-S137
  2. Kulkarni R et al (2012) Comparative pharmacokinetics studies of immediate- and modified-release formulations of glipizide in pigs and dogs. J Pharm Sci '101(11):4327-4336