Gonadotropin releasing hormone
Gonadotropin releasing hormone (GnRH) is a trophic peptide produced by the hypothalamus (pituitary) and causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.
Administration of this drug in male dogs results in a predictable increase in testosterone and the number and activity of sperm. It can thus be used for verification of neuter status in male dogs and hermaphroditism in female dogs.
Depot drugs such as deslorelin can pharmacologically suppress GnRH production and novel immunocontraception regimens have recently attempted to target GnRH as a possible target for endogenous antibody production, using anti-GnRH chemical conjugates. Temporary reduction of LH and testosterone concentrations and decreased testicular volume has been reported, but effects decline after 4 - 5 months.
Recommended dose rate of administration of GnRH in dogs is 20 IU/kg daily, given intramuscularly.
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