Hormone-responsive dermatoses

From Dog

Hormone responsive dermatoses are a group of rare skin diseases characterized by responsiveness to modulation of endogenous hormones.

A number of types have been recognized in dogs:

- Seen in intact male dogs with testicular tumors (e.g. seminoma) and cryptorchidism - more common in the Boxer, Shetland Sheepdog, Weimaraner, German Shepherd, Cairn Terrier, Yorkshire Terrier[1], Pekingese and Collie
- Male pseudohermaphrodite - affecting Miniature Schnauzer - associated with testicular tumors in intact, non-neutered males
  • Hypoestrogenism - ovarian imbalance type II in females - more common in the Boxer and Dachshund
- Occurs after spaying in non-cycling, intact females, occasionally seen during false pregnancy
- Variant - cyclical flank baldness and darkening of the skin in the Airedale, Boxer and English Bulldog
  • Hypertestosteronism - androgen-producing testicular tumors - idiopathic male feminizing syndrome
- Castration responsive in intact males - onset is at one to four years or older
- Predisposition with the Chow Chow, Samoyed, Keeshonden, Pomeranian, Siberian Husky, Alaskan Malamute and Miniature Poodle
  • Hypotestosteronism - testosterone-responsive – in older, castrated males - rare, predisposition with the Afghan Hound
  • Growth hormone-responsive dermatosis[2] - predisposition with Pomeranian, characterized by alopecia and hyperpigmentation of the trunk, caudal portion of the thighs, and ventral neck region.


  1. Kim O & Kim KS (2005) Seminoma with hyperesterogenemia in a Yorkshire Terrier. J Vet Med Sci 67(1):121-123
  2. Schmeitzel LP & Lothrop CD (1990) Hormonal abnormalities in Pomeranians with normal coat and in Pomeranians with growth hormone-responsive dermatosis. J Am Vet Med Assoc 197(10):1333-1341