In most dogs, clinical signs relate to overproduction of estrogen hormones due to neoplasia or congenital hermaphroditism.
Clinically affected dogs present with signs referable to overproduction of estrogen including non-pruritic, bilateral symmetrical alopecia, hyperpigmentation, gynecomastia, edematous and pendulous penile sheath, prostatic dysfunctions, attraction to other males, and standing in a female posture to urinate.
Prostatic dysfunctions may be diagnosed during the development of this syndrome. These include benign prostatic hyperplasia, squamous metaplasia, prostatic adenocarcinoma and prostatic cysts with related symptoms.
In paraneoplastic syndrome, estrogen assays usually confirm increased levels of estrogen. These levels return to normal a few months after surgical removal of the neoplastic testes in sertoli cell tumors.
Retained neoplastic testes are considered to be more predisposed to testicular torsion that can aggravate the clinical signs and result in an inauspicious prognosis.
In female dogs with this condition, ovariohysterectomy is usually curative.
- TPV Experience
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