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Hyperglobulinemia is characterized as an elevated serum level of globulins above the normal range of 21 - 37 g/L.

Globulins are high-molecular weight water-soluble serum proteins composed of immunoglobulins (antibodies) and various hormones and humoral enzymes.

Hyperglobulinemia is frequently caused by chronic inflammation such as inflammatory bowel disease or immune-mediated disease but can also been seen with chronic infections with parasites as well as in Waldenström's macroglobulinemia.

The opposite of hyperglobulinemia is hypoglobulinemia.