Intestinal polyposis

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Characteristic feature of intestinal polyposis from a Jindo dog[1]

Intestinal lymphomatous polyposis is an unusual form of lymphoma characterized by acute gastroenteritis and ileus[1].

Intestinal polyposis manifests in dogs as numerous polyps affecting long segments of the gastrointestinal tract[2]. Lymphomatous polyposis is distinguished from other primary forms of intestinal lymphoma by its poor prognosis and may be intestinal counterpart of human nodal mantle zone lymphoma[3][4].

Clinically affected dogs usually present with progressive anorexia, depression, emaciation and hypoalbuminemia[5].

A presumptive diagnosis may be established by history, abdominal palpation and radiographic/ultrasonographic evidence of markedly thickened intestinal loops and multinodular masses in the serosal layer and irregularly thickened intestinal wall associated with gas-filled loops. Mitotic nuclei are frequently observed within the masses.

A definitive diagnosis requires histological examination of full-thickness intestinal biopsies and immunohistochemistry[6].

Differential diagnoses would include ulcerative colitis (with chronic polyposis formation)[7], intestinal hamartoma[8], neurofibroma, gastric carcinoma (with polypoid formation)[9], adenomatous polyposis (benign) and adenocarcinoma.

Treatment is guarded to poor in most cases and responses to chemotherapy have been limited[10].


  1. 1.0 1.1 Jeong DH et al (2006) Multiple intestinal lymphomatous polyposis in a Jindo dog. J Vet Sci 7(4):401-403
  2. Jubala CM et al (2005) CD20 Expression in Normal Canine B Cells and in Canine non-Hodgkin Lymphoma. Vet Pathol 42:468–476
  3. Isaacson PG et al (1984) Multiple lymphomatous polyposis of the gastrointestinal tract. Histopathology 8:641–656
  4. Hirakawa K et al (1996) Primary gastrointestinal T-cell lymphoma resembling multiple lymphomatous polyposis. Gastroenterology 111:778–782
  5. Jubb KV et al (1993) Pathology of Domestic Animals. Vol. 2. San Diego: Academic Press. pp:140
  6. Lavergne A et al (1994) Multiple lymphomatous polyposis of the gastrointestinal tract. An extensive histopathologic and immunohistochemical study of 12 cases. Cancer 74:3042–3050
  7. Chaimoff C et al (1989) New approach to surgical treatment of ulcerative colitis and polyposis coli without pelvic pouch. Experimental study in dogs. Dis Colon Rectum 32(7):572-579
  8. Bemelmans I et al (2011) Colorectal hamartomatous polyposis and ganglioneuromatosis in a dog. Vet Pathol 48(5):1012-1015
  9. Poutahidis T et al (2008) Primary gastric choriocarcinoma in a dog. J Comp Pathol 139(2-3):146-150
  10. Coyle KA & Steinberg H (2004) Characterization of lymphocytes in canine gastrointestinal lymphoma. Vet Pathol 41:141–146