From Dog

Ivermectin is an injectable macrocyclic lactone effective against endo- and ecto-parasites of dogs[1].

Ivermectin is a macrocyclic lactone derived from fermentation of the bacteria Streptomyces avermitilis. Other avermectins used on dogs include doramectin and selamectin.

Although shown to be effective in off-label use against Dirofilaria immitis and other filariids, bot flies (Cuterebra spp and Cochliomyia spp), fleas and lice, ivermectin has poor efficacy against some dermal mites such as Demodex spp[2]. Some reports shown efficacy against Sarcoptes spp[3].

Ivermectin toxicity has been reported as a common occurrence in Huntaway[4] and Collie breeds.

The recommended dose for injectable ivermectin is 0.1cc/kg SQ stat, or once weekly for ectoparasites.

Oral dose is 24 µg/kg once monthly.


  1. Chittrakarn S et al (2009) Pharmacokinetics of ivermectin in cats receiving a single subcutaneous dose. Res Vet Sci 86(3):503-507
  2. Fisher MA & Shanks DJ (2008) A review of the off-label use of selamectin (Stronghold/Revolution) in dogs and cats. Acta Vet Scand 50:46
  3. Malik R et al (2006) Crusted scabies (sarcoptic mange) in four cats due to Sarcoptes scabiei infestation. J Feline Med Surg 8(5):327-339
  4. Parton K et al (2012) Macrocyclic lactone toxicity due to abamectin in farm dogs without the ABCB1 gene mutation. N Z Vet J 60(3):194-197