Ketoconazole is a triazole antimycotic drug used in severe fungal infections in dogs that are non-responsive to amphotericin B, terbinafine, or other azole drugs such as itraconazole or fluconazole.
Ketoconazole inhibits the fungal-mediated synthesis of ergosterol, resulting in fungal cell wall leakage of ions and resultant death.
Recommended dose rate of ketoconazole is 5 - 15 mg/kg every 12 hours orally for 4 weeks (dermatophytes) or 4 - 6 months (systemic mycoses).
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