Calcium folinate

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(Redirected from Leucovorin)

Calcium folinate (folinic acid; leucovorin) is an adjuvant drug used in chemotherapy with drugs such as methotrexate or 5-fluorouracil[1].

This drug appears to be well tolerated in dogs, with few side-effects[2].

Recommended dose rate in dogs is 3 mg/m2 given intramuscularly.


  1. Lewis DH et al (2010) Use of calcium folinate in the management of accidental methotrexate ingestion in two dogs. J Am Vet Med Assoc 237(12):1450-1454
  2. Cotter SM & Parker LM (1978) High-dose methotrexate and leucovorin rescue in dogs with osteogenic sarcoma. Am J Vet Res 39(12):1943-1945