Malignant pilomatricoma (Pilomatrical carcinoma, Pilomatrix carcinoma) are a cutaneous epithelial cancer characterized by aggressive neoplasic of the hair matrix cells.
Clinically these tumors present as elevated, intradermal masses which vary in size from 1 - 6 cm in diameter. They are usually multilobulated and pigmented, and usually difficult to transect due to bone within the tumor.
These tumors, although locally invasive in the skin of the feet, can spread via lymphatics to peripheral sites.
Histologically, these tumors appear as irregular islands, lobules, and nests of basaloid cells, which transition abruptly into large lakes of keratinized ghost-cells. Differentiation from basal cell carcinoma may be difficult in some cases.
When diagnosed early, these tumors are usually non-metastatic, and wide excision often resolves the condition.
- Uni of Pennsylvania
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