Meclofenamic acid

From Dog

Meclofenamic acid is an NSAID use for management of acute arthritis and osteoarthritis in dogs.

This drug, similar to tolfenamic acid, undergoes extensive enterohepatic recirculation due to its high protein-bound state[1], resulting in delayed onset of activity and prolonged elimination half-life[2].

Meclofenamic acid has little preferential selection for both COX-1 and COX-2 receptors, limiting its long-term use in chronic arthritic cases[3].

Recommended dose rate in dogs is 1.1 mg/kg orally once daily 5 - 7 days.

References

  1. Galbraith EA & McKellar QA (1996) Protein binding and in vitro serum thromboxane B2 inhibition by flunixin meglumine and meclofenamic acid in dog, goat and horse blood. Res Vet Sci 61(1):78-81
  2. Merck Veterinary Manual
  3. Wilson JE et al (2004) Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Am J Vet Res 65(6):810-818