This drug, similar to tolfenamic acid, undergoes extensive enterohepatic recirculation due to its high protein-bound state, resulting in delayed onset of activity and prolonged elimination half-life.
Meclofenamic acid has little preferential selection for both COX-1 and COX-2 receptors, limiting its long-term use in chronic arthritic cases.
Recommended dose rate in dogs is 1.1 mg/kg orally once daily 5 - 7 days.
- Galbraith EA & McKellar QA (1996) Protein binding and in vitro serum thromboxane B2 inhibition by flunixin meglumine and meclofenamic acid in dog, goat and horse blood. Res Vet Sci 61(1):78-81
- Merck Veterinary Manual
- Wilson JE et al (2004) Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Am J Vet Res 65(6):810-818