Microgliomatosis (Gliomatosis cerebri) is a rare brain tumor of dogs characterized by diffuse and widespread infiltration of the central nervous system by neoplastic gliomas of neuroepithelial origin.
Two forms are recognized:
- Type I - classic form characterized by diffuse cerebral infiltration without the formation of a discrete, grossly visible mass.
- Type II - gliomatosis characterized by diffuse infiltrate accompanied by a mass lesion
Affected dogs are usually middle-aged (3 - 9 years) male dogs which usually present with central neurological disease symptoms such as mental depression, nonambulatory tetraparesis, hypermetria, head tilt, ataxia and circling.
A presumptive diagnosis can be established based on CT or MRI imaging, but definitive diagnosis requires histological examination of biopsied brain tissues, often taken postmortem.
The prognosis is many cases is guarded due to the infiltrative nature of this neoplasia and rapid deterioration of clinical symptoms.
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