From Dog

Misoprostol is a synthetic prostaglandin E1 (PGE1) analogue similar in action to dinoprost.

Misoprostol acts upon gastric parietal cells, inhibiting the secretion of gastric acid and reducing proton pump activity in parietal cells.

Because H2-receptor antagonists and proton pump inhibitors are more effective, this drug is reserved for use in retractable cases of gastritis non-responsive to other medication.

This drug is used for the prevention of gastritis[1], in the treatment of vomiting associated with gastrinomas and an adjuvant with aglepristone to induce abortion[2].

Recommended dose in dogs is 2 - 5 μg/kg given orally three to four times daily.


  1. Ward DM et al (2003) The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury. J Vet Intern Med 17(3):282-290
  2. Agaoglu AR et al (2011) The intravaginal application of misoprostol improves induction of abortion with aglepristone. Theriogenology 76(1):74-82