Mycophenolate mofetil

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Mycophenolate mofetil is an immunosuppressant and prodrug of mycophenolic acid used extensively in transplantation medicine.

In dogs, it is sometimes used as adjunct therapy for treatment of myasthenia gravis and in combination with cyclosporine for treatment of Golden Retriever muscular dystrophy, but with limited success[1].

This drug is sometimes given in conjunction with pyridostigmine to improve survival rates in MG-affected dogs[2].

It has also shown to have steroid-sparing effects in the long-term treatment of epidermolysis bullosa[3].

Recommended dose rate in dogs is 20 mg/kg given orally twice daily[4].

References

  1. Wang Z et al (2007) Sustained AAV-mediated dystrophin expression in a canine model of Duchenne muscular dystrophy with a brief course of immunosuppression. Mol Ther 15:1160–1166
  2. Dewey CW et al (2010) Mycophenolate mofetil treatment in dogs with serologically diagnosed acquired myasthenia gravis: 27 cases (1999-2008). J Am Vet Med Assoc 236(6):664-668
  3. Ginel PJ et al (2010) Steroid-sparing effect of mycophenolate mofetil in the treatment of a subepidermal blistering autoimmune disease in a dog. J S Afr Vet Assoc 81(4):253-257
  4. Shin JH et al (2012) A simplified immune suppression scheme leads to persistent micro-dystrophin expression in Duchenne muscular dystrophy dogs. Hum Gene Ther 23(2):202-209
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