Myxosarcoma are a locally invasive and metastatic tumor of canine connective tissue.
These are a malignant tumor of primitive pleomorphic fibroblasts that produce excess mucin.
These slowly growing tumors will cause clinical signs only when they impinge on adjacent structures. Primary tumors have been reported in the long bones, subcutaneous connective tissue, vertebrae, skull, brain, heart, pericardium and lungs (endobronchial polyposis).
Clinically affected dogs often present with cardiac or pulmonary involvement, and symptoms include pyrexia, dyspnoea and tachycardia. Regional lymphadenopathy may be observed with cutaneous myxosarcomas.
Diagnosis is based on clinical presentation with supportive histopathology examination of biopsied material.
These tumors commonly appear as atypical mesenchymal cells in a dense eosinophilic background, interpreted as consistent with the presence of a matrix-secreting tumour.
Treatment usually involves wide-margin surgical resection with or without radiation therapy.
The prognosis is usually good but recurrence is common.
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