From Dog

Neostigmine is a long-acting anticholinesterase drug primarily used for treatment of canine myasthenia gravis[1].

Recommended dose rate is 0.04 mg/kg given subcutaneously four times daily[2].

Cholinergic crises have been reported in dogs following use of this drug and it should be used with caution.

Recommended dose rate in dogs is 0.05 mg/kg given subcutaneously as a single dose or 0.04 mg/kg every 6 hours.


  1. Webb AA et al (1997) Focal myasthenia gravis in a dog. Can Vet J 38(8):493-495
  2. Foy, DS et al (2011) Cholinergic crisis after neostigmine administration in a dog with acquired focal myasthenia gravis. J Vet Emerg Crit Care (San Antonio) 21(5):547-551