Papillary adenocarcinoma

From Dog
A papillary adenocarcinoma removed from a 10-year-old Golden Retriever[1]

Papillary adenocarcinoma are a malignant epithelial tumor of the canine ovary.

Unlike their benign counterpart, the papillary adenoma, these tumors are more aggressive and can grow to a significant size and result in peritoneal implantation metastasis[2].

Clinical symptoms are often nonspecific and may include anestrus in non-sterilized bitches, abdominal pain and a palpable mass in the central abdomen.

A presumptive diagnosis is usually achieved with abdominal ultrasonography, showing a mass lesion effect.

A definitive diagnosis includes granulosa cell tumor, ovarian teratomas, paraovarian cysts, ovarian carcinoma and dysgerminoma[3].

Treatment is usually curative with ovariohysterectomy.


  1. Hori Y et al (2006) Canine ovarian serous papillary adenocarcinoma with neoplastic hypercalcemia. J Vet Med Sci 68(9):979-982
  2. Nielsen SW et al (1976) Tumours of the ovary. Bull World Health Organ 53(2-3):203-215
  3. Bertazzolo W et al (2004) Cytological features of canine ovarian tumours: a retrospective study of 19 cases. J Small Anim Pract 45(11):539-545