Parathyroid hormone (PTH), secreted by the chief cells of the parathyroid glands, causes an increased in serum calcium.
Plasma calcium is regulated within a narrow serum range, by thyroxine, vitamin D and PTH, with mobilization and deposition of calcium from stores in tissue and bone, as well as direct uptake from the gut. Multiple metabolic fragments of PTH in circulation are cleared by glomerular filtration and only intact PTH molecule is metabolically active.
Hypercalcemic dogs with non-parathyroidal disease should have low to low-normal basal PTH. Elevated or high normal PTH in hypercalcemic dog is suggestive of primary hyperparathyroidism or parathyroid carcinoma.
Following parathyroidectomy, levels of PTH drop markedly and calcium and vitamin D supplementation may be required.
Normal PTH range in dogs is 2 - 13 pmol/L.
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