Pentosan polysulfate

From Dog

Pentosan polysulfate sodium (PPS) has a heparin-like structure and was originally purified from the plant of European beech wood.

PPS has been used for the treatment of interstitial cystitis for human patients and was recognized to have unique anti-inflammatory properties.

It is primarily used in canine medicine for long-term palliative and restorative cartilage effects associated with osteoarthritis, although its effect are only moderate at alleviating joint pain[1].

It may be a useful adjunctive treatment option when used in association with other palliative medications[2].

Recommended dose is 3 - 5 mg/kg on four occasions, with an interval of 5 – 7 days.


  1. Sanderson RO et al (2009) Systematic review of the management of canine osteoarthritis. Vet Rec 164(14):418-424
  2. Budsberg SC et al (2007) Evaluation of pentosan polysulfate sodium in the postoperative recovery from cranial cruciate injury in dogs: a randomized, placebo-controlled clinical trial. Vet Surg 36(3):234-244