Peripheral giant cell granuloma
Although the cause of these benign tumors is unknown, in humans there is a close relationship between giant cell granulomas and multinucleate cells to osteoclasts, suggesting that local periosteal inflammation or trauma may stimulate proliferation of mesenchymal progenitor cells leading to the formation of osteoclastic and osteoblastic cells.
Characteristic histological features are similar to those with giant cell tumor, with vascular gingival masses composed of large numbers of multinucleated giant cells in a background of mononuclear stromal cells. Areas of hemorrhage and hemosiderosis are also common.
Diagnosis requires histopathological analysis of biopsied material.
Treatment usually necessitates wide extirpation of the lesion or rim mandibulectomy.
- Gardner DG (1996) Epulides in the dog: a review. J Oral Pathol Med 25(1):32-37
- Sapp JP (1972) Ultrastructure and histogenesis of peripheral giant cell reparative granuloma of the jaws. Cancer 30:1119
- Saygun I et al (2009) Human cytomegalovirus in peripheral giant cell granuloma. Oral Microbiol Immunol 24(5):408-410
- Trigo FJ et al (1983) A comparison of canine giant cell tumor and giant cell reparative granuloma of bone. Vet Pathol 20(2):215-222
- Desoutter AV et al (2012) Clinical and Histologic Features of 26 Canine Peripheral Giant Cell Granulomas (Formerly Giant Cell Epulis). Vet Pathol Mar 12