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Procarbazine is an alkylating agent used for the treatment canine lymphoma. Procarbazine is T cell-specific and crosses the blood-brain barrier[1].

It also has immunosuppressive effects.

Recommended dose is 25 - 50 mg/m2 per day on a 21 day cycle.

Procarbazine can sometimes cause neurotoxicity, but myelosuppression (thrombocytopenia, leukopenia) seems to be the major limiting factor.


  1. Coates JR et al (2007) Procarbazine as adjunctive therapy for treatment of dogs with presumptive antemortem diagnosis of granulomatous meningoencephalomyelitis: 21 cases (1998-2004). J Vet Intern Med 21(1):100-106