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It also has immunosuppressive effects.
Recommended dose is 25 - 50 mg/m2 per day on a 21 day cycle.
Procarbazine can sometimes cause neurotoxicity, but myelosuppression (thrombocytopenia, leukopenia) seems to be the major limiting factor.
- Coates JR et al (2007) Procarbazine as adjunctive therapy for treatment of dogs with presumptive antemortem diagnosis of granulomatous meningoencephalomyelitis: 21 cases (1998-2004). J Vet Intern Med 21(1):100-106