From Dog

Proligestone is a synthetic steroidal progesterone drug (progestin).

Proligestone induces suppression of the hypothalamic-pituitary-adrenal axis, resulting in suppression of corticotrophin-releasing hormone and plasma glucocorticoid levels[1], reduced insulin sensitivity and a predisposition to diabetes mellitus, mammary hyperplasia and acromegaly[2].

This drug is used for estrus suppression, aggression, pseudopregnancy and treatment of pituitary dwarfism[3].

Side-effects include steroid-induced hepatopathy, chronic pyelonephritis, aspecific dermatitis and mucinous dysplasia of the gall bladder[4].

Recommended dose is 5 mg/kg.


  1. Selman PJ et al (1996) Binding specificity of medroxyprogesterone acetate and proligestone for the progesterone and glucocorticoid receptor in the dog. Steroids 61(3):133-137
  2. Selman PJ et al (1997) Effects of progestin administration on the hypothalamic-pituitary-adrenal axis and glucose homeostasis in dogs. J Reprod Fertil Suppl 51:345-354
  3. Knottenbelt CM & Herrtage ME (2002) Use of proligestone in the management of three German shepherd dogs with pituitary dwarfism. J Small Anim Pract 43(4):164-170
  4. Selman PJ et al (1995) Comparison of the histological changes in the dog after treatment with the progestins medroxyprogesterone acetate and proligestone. Vet Q 17(4):128-133