Although primary pulmonary lymphomas are usually T-cell based, primary B-cell pulmonary lymphomas can also occur and are characterized by lymphomatoid granulomatosis. This condition is characterized by multiple pulmonary nodules that consist of sheets of atypical lymphoreticular and plasmacytoid cells admixed with fewer mature eosinophils and lymphocytes.
Diagnosis is usually based on radiographic, echocardiographic and CT imaging studies which usually show multiple or discrete pulmonary masses with mineralization, variable degrees of tracheobronchial lymphadenopathy, pleural effusion and cardiomegaly.
A definitive diagnosis requires histological examination of ultrasound-guided biopsy or surgical biopsies.
Adjunct therapy with radiation or in terminal cases, palliative anti-inflamamtory drugs such as prednisolone have also been reported.
Prinary T-cell lymphomas and evidence of anterior pulmonary lymphadenopathy are usually associated with poorer survival in dogs.
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