Unlike other drugs in this class such as ketoprofen, it can be used for long-term manangement of diseases such as osteoarthritis without significant renal, hepatic of gastrointestinal side-effects.
This drug has also shown efficacy as a parenterally administered peri-operative analgesic for use in routine surgery (e.g. ovariohysterectomy) or orthopedic procedures, significantly reducing acute joint pain and inflammation.
Robenacoxib is an acidic NSAID and is highly bound to plasma proteins with the result that it concentrates in inflamed tissues such as an arthritic joint, thereby displaying the property of tissue selectivity.
Recommended dose rate in dogs is 1.0 - 2.0 mg/kg given orally once daily.
- Bennett D et al (2013) The effect of robenacoxib on the concentration of C-reactive protein in synovial fluid from dogs with osteoarthritis. BMC Vet Res 9:42
- Edamura K et al (2012) Comparison of oral robenacoxib and carprofen for the treatment of osteoarthritis in dogs: a randomized clinical trial. J Vet Med Sci 74(9):1121-1131
- Reymond N et al (2012) Robenacoxib vs. carprofen for the treatment of canine osteoarthritis; a randomized, noninferiority clinical trial. J Vet Pharmacol Ther 35(2):175-183
- King JN et al (2011) Robenacoxib in the dog: target species safety in relation to extent and duration of inhibition of COX-1 and COX-2. J Vet Pharmacol Ther 34(3):298-311
- Silber HE et al (2010) Population pharmacokinetic analysis of blood and joint synovial fluid concentrations of robenacoxib from healthy dogs and dogs with osteoarthritis. Pharm Res 27(12):2633-2645
- King JN et al (2010) In vitro and ex vivo inhibition of canine cyclooxygenase isoforms by robenacoxib: a comparative study. Res Vet Sci 88(3):497-506
- Gruet P et al (2011) Evaluation of subcutaneous and oral administration of robenacoxib and meloxicam for the treatment of acute pain and inflammation associated with orthopedic surgery in dogs. Am J Vet Res 72(2):184-193
- Schmid VB et al (2010) Analgesic and anti-inflammatory actions of robenacoxib in acute joint inflammation in dog. J Vet Pharmacol Ther 33(2):118-131
- Silber HE et al (2010) Population pharmacokinetic analysis of blood and joint synovial fluid concentrations of robenacoxib from healthy dogs and dogs with osteoarthritis. Pharm Res 27:2633–2645
- Brune K & Furst D (2007) Combining enzyme specificity and tissue selectivity of cyclooxygenase inhibitors: towards better tolerability? Rheumatology 46:911–919