Robenacoxib

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Robenacoxib is a NSAID drug which has analgesic, anti-inflammatory and antipyretic properties[1] similar to that of carprofen[2][3].

This drug has a relatively high safety index due to its selective COX-2 specificity, short circulatory half-life and prolonged tissue compartmentalization[4][5].

Unlike other drugs in this class such as ketoprofen, it can be used for long-term manangement of diseases such as osteoarthritis[6] without significant renal, hepatic of gastrointestinal side-effects.

This drug has also shown efficacy as a parenterally administered peri-operative analgesic for use in routine surgery (e.g. ovariohysterectomy) or orthopedic procedures[7], significantly reducing acute joint pain and inflammation[8].

Robenacoxib is an acidic NSAID and is highly bound to plasma proteins with the result that it concentrates in inflamed tissues such as an arthritic joint[9], thereby displaying the property of tissue selectivity[10].

Recommended dose rate in dogs is 1.0 - 2.0 mg/kg given orally once daily.

References

  1. Bennett D et al (2013) The effect of robenacoxib on the concentration of C-reactive protein in synovial fluid from dogs with osteoarthritis. BMC Vet Res 9:42
  2. Edamura K et al (2012) Comparison of oral robenacoxib and carprofen for the treatment of osteoarthritis in dogs: a randomized clinical trial. J Vet Med Sci 74(9):1121-1131
  3. Reymond N et al (2012) Robenacoxib vs. carprofen for the treatment of canine osteoarthritis; a randomized, noninferiority clinical trial. J Vet Pharmacol Ther 35(2):175-183
  4. King JN et al (2011) Robenacoxib in the dog: target species safety in relation to extent and duration of inhibition of COX-1 and COX-2. J Vet Pharmacol Ther 34(3):298-311
  5. Silber HE et al (2010) Population pharmacokinetic analysis of blood and joint synovial fluid concentrations of robenacoxib from healthy dogs and dogs with osteoarthritis. Pharm Res 27(12):2633-2645
  6. King JN et al (2010) In vitro and ex vivo inhibition of canine cyclooxygenase isoforms by robenacoxib: a comparative study. Res Vet Sci 88(3):497-506
  7. Gruet P et al (2011) Evaluation of subcutaneous and oral administration of robenacoxib and meloxicam for the treatment of acute pain and inflammation associated with orthopedic surgery in dogs. Am J Vet Res 72(2):184-193
  8. Schmid VB et al (2010) Analgesic and anti-inflammatory actions of robenacoxib in acute joint inflammation in dog. J Vet Pharmacol Ther 33(2):118-131
  9. Silber HE et al (2010) Population pharmacokinetic analysis of blood and joint synovial fluid concentrations of robenacoxib from healthy dogs and dogs with osteoarthritis. Pharm Res 27:2633–2645
  10. Brune K & Furst D (2007) Combining enzyme specificity and tissue selectivity of cyclooxygenase inhibitors: towards better tolerability? Rheumatology 46:911–919
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