From Dog

S-Adenosylmethionine (SAMe), a common cosubstrate involved in methyl group transfers, is a glutathione replenisher.

It thus acts as a potent antioxidant and cytoprotective agent that protects cells from toxins and cell death.

S-Adenosylmethionine's properties are similar to those of N-acetylcysteine, ursodeoxycholic acid, silymarin and vitamin E[1].

This drug is sometimes incorporated together with silymarin as a more potent antioxidant in use with chemotherapy agents such as lomustine[2].

S-Adenosylmethionine is also used as a supportive hepatic drug in dogs with cognitive deficit syndrome[3], reperfusion injuries[4], acetaminophen toxicity[5], chronic hepatitis, hepatitis[6], hepatic encephalopathy and portosystemic shunt.

It appears ineffective at ameliorating clinical signs associated with osteoarthritis in dogs[7].

The recommended dose rate in dogs is 20 - 30 mg/kg given orally as a daily dose.


  1. Webster CR & Cooper J (2009) Therapeutic use of cytoprotective agents in canine and feline hepatobiliary disease. Vet Clin North Am Small Anim Pract 39(3):631-652
  2. Skorupski KA et al (2011) Prospective randomized clinical trial assessing the efficacy of Denamarin for prevention of CCNU-induced hepatopathy in tumor-bearing dogs. J Vet Intern Med 25(4):838-845
  3. Rème CA et al (2008) Effect of S-adenosylmethionine tablets on the reduction of age-related mental decline in dogs: a double-blinded, placebo-controlled trial. Vet Ther 9(2):69-82
  4. Buckley GJ et al (2009) Massive transfusion and surgical management of iatrogenic aortic laceration associated with cystocentesis in a dog. J Am Vet Med Assoc 235(3):288-291
  5. Wallace KP et al (2002) S-adenosyl-L-methionine (SAMe) for the treatment of acetaminophen toxicity in a dog. J Am Anim Hosp Assoc 38(3):246-254
  6. Center SA et al (2005) Evaluation of the influence of S-adenosylmethionine on systemic and hepatic effects of prednisolone in dogs. Am J Vet Res 66(2):330-341
  7. Imhoff DJ et al (2011) Evaluation of S-adenosyl l-methionine in a double-blinded, randomized, placebo-controlled, clinical trial for treatment of presumptive osteoarthritis in the dog. Vet Surg 40(2):228-232