From Dog

Tacrolimus is an immunosuppressive drug used in dogs for various diseases such as otitis externa and perianal fistulas.

Tacrolimus is a macrolide lactone formed from the fermentation of Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) production by T-cells[1].

With chronic superficial keratitis, treatment with ocular drops containing 0.02% tacrolimus and 50% DMSO, administered to the ocular surface three times a day, have shown to be efficacious[2].

It is usually available as a 1.0% ointment to be applied topically twice daily.


  1. Kino, T et al (1987) FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. J Antibiot (Tokyo) 40(9): 1249–1255
  2. Balicki I (2012) Clinical study on the application of tacrolimus and DMSO in the treatment of chronic superficial keratitis in dogs. Pol J Vet Sci 15(4):667-676