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Mitotane (Lysodren; o,p'-DDD) is an antineoplastic medication used in the treatment of canine hyperadrenocorticism which occurs as a result of pituitary adenoma or pituitary adenocarcinoma[1].

Mitotane is used in adrenal cancer as adjuvant therapy, monotherapy or combined with other cytotoxic agents in advanced disease.

Side-effects include drug-induced hypoadrenocorticism.

Recommended dose rate in dogs is 50 mg/kg orally once daily for five days, then once weekly maintenance therapy. However, as body weight increases, dose/kg or dosage/day of trilostane required to control the clinical signs of PDH decreases. Dogs weighing >30 kg might require smaller amounts of trilostane per dose or per day[2].


  1. Reine NJ (2012) Medical management of pituitary-dependent hyperadrenocorticism: mitotane versus trilostane. Top Companion Anim Med 27(1):25-30
  2. Feldman EC & Kass PH (2012) Trilostane dose versus body weight in the treatment of naturally occurring pituitary-dependent hyperadrenocorticism in dogs. J Vet Intern Med 26(4):1078-1080