Achondroplasia (dwarfism; short limbs) is an autosomal-recessive genetic disease of dogs characterized by disproportionate dwarfism, macrocephaly, facial hypoplasia and vertebral malformations.
This disease, commonly reported in the German Shepherd, is associated with a failure of the oropharyngeal ectoderm of the cranial pharyngeal duct. Craniopharyngiomas also cause subnormal secretion of growth hormone, which results in dwarfism.
In typical cases of achondroplasia, affected pups are born with severe anatomical deformities such as dorsoventral flattening of the thoracic cavity, malpositioning of the scapula and enlarged, disproportionate heads.
- Pedigree Database
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